Chk2(Phospho Thr383) Polyclonal Antibody

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutati

Introducing the Chk2(Phospho Thr383) Polyclonal Antibody, a highly specialized and meticulously crafted product designed to cater to the discerning needs of the scientific community. This antibody, developed through rigorous research and development processes, exhibits exceptional specificity and sensitivity in detecting the phosphorylation of threonine residue 383 on the Chk2 protein.

With its polyclonal nature, this antibody offers a comprehensive and versatile solution for various applications, including immunoblotting, immunoprecipitation, and immunofluorescence. Its ability to recognize the phosphorylated form of Chk2 at Thr383 enables precise and accurate analysis of cellular signaling pathways involved in DNA damage response and cell cycle regulation.

The Chk2(Phospho Thr383) Polyclonal Antibody is meticulously manufactured using state-of-the-art techniques, ensuring batch-to-batch consistency and reliability. Its high affinity and low background reactivity guarantee optimal performance, facilitating the detection and quantification of phosphorylated Chk2 with utmost precision.

This antibody is supplied in a convenient and user-friendly format, allowing for seamless integration into various experimental protocols. Its compatibility with multiple species, including human, mouse, and rat, further enhances its versatility and applicability across diverse research fields.

In summary, the Chk2(Phospho Thr383) Polyclonal Antibody stands as a testament to our commitment to delivering cutting-edge tools for scientific exploration. Its exceptional specificity, sensitivity, and versatility make it an indispensable asset for researchers seeking to unravel the intricacies of cellular signaling pathways and advance our understanding of fundamental biological processes.