Chk2(Phospho Ser516) Polyclonal Antibody

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutati

The Chk2(Phospho Ser516) Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Chk2 protein phosphorylated at Ser516. This antibody is produced using high-quality polyclonal antibodies that have been rigorously tested for specificity and sensitivity. The Chk2(Phospho Ser516) Polyclonal Antibody is ideal for use in a variety of applications, including Western blotting, immunoprecipitation, and immunohistochemistry. This antibody is suitable for use in both research and diagnostic applications and has been validated for use in human, mouse, and rat samples. With its high specificity and sensitivity, the Chk2(Phospho Ser516) Polyclonal Antibody is an essential tool for researchers and clinicians working in the field of cancer biology and other related fields.

The CHK2(PHOSPHO SER516) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of CHK2 protein phosphorylated at serine 516. This antibody is produced using advanced polyclonal antibody technology, ensuring exceptional sensitivity and specificity in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

The CHK2 protein plays a crucial role in the cellular response to DNA damage and is involved in cell cycle regulation and DNA repair processes. Phosphorylation of CHK2 at serine 516 is a key event in its activation and subsequent signaling cascade. Therefore, the CHK2(PHOSPHO SER516) Polyclonal Antibody serves as an invaluable tool for researchers studying the intricate mechanisms of DNA damage response and cell cycle control.

This antibody exhibits outstanding performance in various experimental settings, providing robust and reproducible results. Its high affinity and specificity ensure minimal cross-reactivity with non-phosphorylated CHK2 or other proteins, guaranteeing accurate and reliable data interpretation.

The CHK2(PHOSPHO SER516) Polyclonal Antibody is supplied in a convenient and ready-to-use format, allowing for immediate application in your research. It is produced using high-quality materials and undergoes rigorous quality control to ensure consistent performance and batch-to-batch reproducibility.

Choose the CHK2(PHOSPHO SER516) Polyclonal Antibody for your research needs and unlock the potential of investigating CHK2 phosphorylation at serine 516 with confidence and precision.