Cdk9(Phospho Thr186) Polyclonal Antibody

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.

The Cdk9(Phospho Thr186) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Cdk9 protein phosphorylated at threonine 186. This antibody is produced using advanced techniques to ensure high affinity and specificity, making it an ideal choice for various applications in molecular biology and biomedical research.

Cdk9, also known as cyclin-dependent kinase 9, plays a crucial role in regulating transcriptional elongation by phosphorylating the C-terminal domain of RNA polymerase II. Phosphorylation of Cdk9 at threonine 186 has been implicated in the activation of Cdk9 and its subsequent involvement in gene expression and cell cycle progression.

The Cdk9(Phospho Thr186) Polyclonal Antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated Cdk9 and other related proteins, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation, ready to use for direct application in various experimental techniques. It is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins. The antibody is provided in a convenient size and concentration, allowing for multiple experiments and minimizing wastage.

With its exceptional performance and reliability, the Cdk9(Phospho Thr186) Polyclonal Antibody is an indispensable tool for researchers studying the intricate mechanisms of transcriptional regulation, cell cycle control, and gene expression. Its high specificity and sensitivity make it an invaluable asset in elucidating the role of Cdk9 phosphorylation in various physiological and pathological processes.

Order your Cdk9(Phospho Thr186) Polyclonal Antibody today and unlock new insights into the complex world of molecular biology.