Cdk1/2/3(Phospho Thr14) Polyclonal Antibody

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

The Cdk1/2/3(Phospho Thr14) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Cdk1, Cdk2, and Cdk3 proteins phosphorylated at the threonine 14 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target proteins.

Cyclin-dependent kinases (Cdks) play a crucial role in regulating the cell cycle and are involved in various cellular processes, including DNA replication, transcription, and cell division. Phosphorylation of Cdks at specific residues is a key mechanism for their activation and regulation. The phosphorylation of threonine 14 residue in Cdk1, Cdk2, and Cdk3 has been shown to be critical for their proper function and activity.

The Cdk1/2/3(Phospho Thr14) Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated forms of Cdks and other related proteins, ensuring accurate and reliable results.

This antibody is supplied as a purified and lyophilized form, allowing for long-term storage and convenient reconstitution. It is recommended for use in both basic research and clinical applications, providing valuable insights into the regulation and function of Cdk1, Cdk2, and Cdk3 proteins.

In summary, the Cdk1/2/3(Phospho Thr14) Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of phosphorylated Cdk1, Cdk2, and Cdk3 proteins. Its advanced technology, extensive validation, and convenient formulation make it an ideal choice for researchers and clinicians studying cell cycle regulation and related processes.