Caspase-3 Polyclonal Antibody

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

The CASPASE 3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of CASPASE 3 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a specific region of the CASPASE 3 protein. It has been extensively validated for its specificity and affinity towards CASPASE 3, ensuring reliable and accurate results.

The CASPASE 3 Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes both the proenzyme and the active form of CASPASE 3, enabling the detection of total CASPASE 3 protein levels as well as its activation status. This antibody demonstrates minimal cross-reactivity with other caspases, ensuring specific and precise detection of CASPASE 3.

With its high sensitivity, the CASPASE 3 Polyclonal Antibody allows for the detection of low-abundance CASPASE 3 protein in samples with limited availability. It offers a reliable and reproducible solution for researchers studying apoptosis, as CASPASE 3 plays a crucial role in this process. The antibody's robust performance and consistent results make it an ideal choice for both basic research and clinical applications.

The CASPASE 3 Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, ensuring cost-effective and efficient experiments. The antibody is manufactured under strict quality control standards, guaranteeing batch-to-batch consistency and reliability.

In summary, the CASPASE 3 Polyclonal Antibody is a highly specific and sensitive tool that enables accurate detection and quantification of CASPASE 3 protein. Its exceptional performance, versatility, and reliability make it an invaluable asset for researchers in the field of apoptosis and beyond.