Calreticulin Rabbit Polyclonal Antibody

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its

The Calreticulin Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of calreticulin protein in various biological samples. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring exceptional performance and reliability.

Calreticulin is a multifunctional protein that plays a crucial role in calcium homeostasis, protein folding, and cellular signaling pathways. It is predominantly located in the endoplasmic reticulum (ER) and is involved in the regulation of ER stress response. Dysregulation of calreticulin expression or function has been implicated in various pathological conditions, including cancer, autoimmune diseases, and neurodegenerative disorders.

The Calreticulin Rabbit Polyclonal Antibody exhibits excellent specificity, displaying minimal cross-reactivity with other proteins, thus enabling accurate and precise detection of calreticulin. It has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

This antibody offers exceptional sensitivity, allowing for the detection of low levels of calreticulin protein in even the most challenging samples. Its high affinity and avidity ensure reliable and reproducible results, making it an ideal choice for both research and diagnostic purposes.

The Calreticulin Rabbit Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. Each batch of this antibody undergoes rigorous quality control testing to ensure consistent performance and batch-to-batch reproducibility.

In summary, the Calreticulin Rabbit Polyclonal Antibody is a valuable tool for researchers and clinicians alike, offering exceptional specificity, sensitivity, and reliability. Its versatility and ease of use make it an indispensable asset in the study of calreticulin biology and its implications in various diseases.