Bmi-1 Rabbit Polyclonal Antibody(F270)

This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.

The Bmi-1 Rabbit Polyclonal Antibody (F270) is a highly specific and reliable tool designed for the detection and analysis of Bmi-1 protein expression in various biological samples. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring exceptional sensitivity and specificity.

Bmi-1, also known as B-lymphoma Mo-MLV insertion region 1, is a key regulator of cell proliferation and self-renewal in various stem cell populations. It plays a crucial role in maintaining the balance between stem cell self-renewal and differentiation. Dysregulation of Bmi-1 expression has been implicated in various diseases, including cancer and neurodegenerative disorders.

The Bmi-1 Rabbit Polyclonal Antibody (F270) has been extensively validated for its performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications. It exhibits excellent specificity, minimal cross-reactivity, and high affinity towards Bmi-1 protein, enabling accurate and reliable detection.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size of 100 µg, ensuring ample quantity for multiple experiments. The Bmi-1 Rabbit Polyclonal Antibody (F270) is compatible with a wide range of sample types, including formalin-fixed paraffin-embedded (FFPE) tissues, frozen sections, and cell lysates.

With its exceptional performance and versatility, the Bmi-1 Rabbit Polyclonal Antibody (F270) is an indispensable tool for researchers and clinicians involved in stem cell biology, cancer research, and related fields. Its reliable and accurate detection capabilities make it an invaluable asset in understanding the role of Bmi-1 in various physiological and pathological processes.