AXIN1 Polyclonal Antibody

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants.

The AXIN1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of AXIN1 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards AXIN1.

AXIN1 is a crucial component of the Wnt signaling pathway, playing a pivotal role in the regulation of cell proliferation, differentiation, and development. Dysregulation of AXIN1 has been implicated in various diseases, including cancer and developmental disorders. Therefore, accurate detection and quantification of AXIN1 expression are of utmost importance in understanding its functional significance and potential therapeutic implications.

The AXIN1 Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It demonstrates minimal cross-reactivity with other proteins, ensuring reliable and accurate results. With its high sensitivity, this antibody allows for the detection of low levels of AXIN1 expression, enabling researchers to explore its role in different biological contexts.

This product is supplied as a liquid formulation, ready for immediate use. It is available in different sizes to accommodate various experimental needs. Each batch of the AXIN1 Polyclonal Antibody undergoes rigorous quality control testing to ensure consistent and reliable performance.

In summary, the AXIN1 Polyclonal Antibody is a valuable tool for researchers studying the Wnt signaling pathway and its associated diseases. Its high specificity, sensitivity, and versatility make it an essential component of any AXIN1-related research project.