ANPRB Polyclonal Antibody

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.

The ANPRB Polyclonal Antibody is a highly specific and sensitive antibody designed for use in various research applications. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of the ANPRB protein. The resulting polyclonal antibody is purified using a combination of protein A and protein G chromatography, ensuring high purity and specificity.

The ANPRB Polyclonal Antibody has been extensively validated for use in Western blotting, immunohistochemistry, and immunofluorescence assays. It has been shown to specifically recognize the ANPRB protein in a variety of tissues and cell types, making it an ideal tool for studying the function and regulation of this important protein.

This antibody is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is available in various sizes to suit different experimental needs. The ANPRB Polyclonal Antibody is a reliable and high-quality reagent that can help advance research in the fields of cardiovascular disease, hypertension, and other related areas.