NFκB-p105(Phospho Ser893) Polyclonal Antibody

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines| oxidant-free radicals| ultraviolet irradiation| and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isof

The NFκB-p105(Phospho Ser893) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of NFκB-p105 protein phosphorylated at Ser893. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

NFκB-p105 is a crucial transcription factor involved in various cellular processes, including immune response, inflammation, and cell survival. Phosphorylation of NFκB-p105 at Ser893 has been shown to play a critical role in regulating its activity and downstream signaling pathways.

This polyclonal antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated NFκB-p105 and other related proteins, ensuring accurate and reliable results.

The NFκB-p105(Phospho Ser893) Polyclonal Antibody is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage. It is recommended for use in both research and clinical applications, including the study of NFκB-p105 phosphorylation dynamics, protein-protein interactions, and the development of therapeutic strategies targeting NFκB signaling.

With its exceptional specificity, sensitivity, and reliability, the NFκB-p105(Phospho Ser893) Polyclonal Antibody is an indispensable tool for researchers and scientists working in the field of NFκB signaling and related areas.