ZP3 Rabbit Polyclonal Antibody

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence| a conserved ZP domain| a C-terminal consensus furin cleavage site| and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However| the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however| sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3| including the above described variation| and maps closely to this gene.

The ZP3 Rabbit Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Zona Pellucida 3 (ZP3) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a specific region of the ZP3 protein.

The ZP3 Rabbit Polyclonal Antibody exhibits exceptional sensitivity and specificity, making it an ideal choice for a wide range of applications, including immunohistochemistry, western blotting, and enzyme-linked immunosorbent assays (ELISA). It recognizes the ZP3 protein in multiple species, including human, mouse, and rat, ensuring its versatility and applicability in diverse research settings.

With its high affinity and low background, this antibody enables accurate and precise detection of ZP3 protein, facilitating the investigation of its role in reproductive biology and fertility. Its robust performance guarantees reliable and reproducible results, allowing researchers to obtain valuable insights into the molecular mechanisms underlying fertilization processes.

The ZP3 Rabbit Polyclonal Antibody is supplied as a liquid formulation, ensuring ease of use and convenience. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex preparation steps. The antibody is also available in various sizes to accommodate different experimental requirements.

In summary, the ZP3 Rabbit Polyclonal Antibody is a highly specific and sensitive tool that enables the detection and analysis of ZP3 protein in various biological samples. Its exceptional performance, versatility, and ease of use make it an indispensable asset for researchers studying reproductive biology and fertility.