TRAF2(Phospho-Ser11) Rabbit Polyclonal Antibody

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with| and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors| and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs)| and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD| a TNF receptor associated apoptotic signal transducer| ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1| an apoptosis inhibitor possessing ubiquitin ligase activity| can unbiquitinate and induce the degradation of this pro

The TRAF2(Phospho-Ser11) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of TRAF2 protein phosphorylated at Serine 11. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring reliable and reproducible results.

TRAF2, also known as TNF receptor-associated factor 2, is a key signaling molecule involved in various cellular processes, including immune response, inflammation, and cell survival. Phosphorylation of TRAF2 at Serine 11 has been shown to regulate its activity and function, making it an important target for research in the field of signal transduction.

The TRAF2(Phospho-Ser11) Rabbit Polyclonal Antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated TRAF2 and other related proteins, ensuring accurate and reliable detection of phosphorylated TRAF2.

This antibody is supplied as a liquid formulation, ready to use for various applications in molecular biology and cell biology research. It is recommended for use in both in vitro and in vivo studies, including protein expression analysis, protein-protein interaction studies, and functional assays.

With its high specificity, sensitivity, and reliability, the TRAF2(Phospho-Ser11) Rabbit Polyclonal Antibody is an essential tool for researchers studying the role of TRAF2 phosphorylation in cellular signaling pathways and disease mechanisms.