Topoisomerase II alpha(Phospho-Ser1469) Rabbit Polyclonal Antibody

This gene encodes a DNA topoisomerase| an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation| chromatid separation| and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another| thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form| alpha| is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also plaThe Topoisomerase II alpha(Phospho-Ser1469) Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of Topoisomerase II alpha protein phosphorylated at Ser1469. This antibody has been rigorously tested and validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

Topoisomerase II alpha is an essential enzyme involved in DNA replication, transcription, and chromosome segregation. Phosphorylation of Topoisomerase II alpha at Ser1469 has been implicated in regulating its enzymatic activity and cellular functions. This antibody specifically recognizes the phosphorylated form of Topoisomerase II alpha at Ser1469, enabling researchers to study the role of this post-translational modification in various biological processes.

The Topoisomerase II alpha(Phospho-Ser1469) Rabbit Polyclonal Antibody exhibits high specificity and sensitivity, ensuring accurate and reliable results. It has been extensively validated using various cell lines and tissues, demonstrating its robust performance across different experimental conditions.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy handling and storage. The Topoisomerase II alpha(Phospho-Ser1469) Rabbit Polyclonal Antibody is an indispensable tool for researchers studying DNA replication, transcription, and chromosome dynamics, providing valuable insights into the regulation and function of Topoisomerase II alpha.