TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody

Catalytic activity:ATP-dependent breakage| passage and rejoining of double-stranded DNA.|enzyme regulation:Specifically inhibited by the intercalating agent amsacrine.|Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.|miscellaneous:Eukaryotic topoisomerase I and II can relax both negative and positive supercoils| whereas prokaryotic enzymes relax only negative supercoils.|PTM:Phosphorylation has no effect on Catalytic activity.|Belongs to the type II topoisomerase family.|subcellular location:Generally located in the nucleoplasm.|subunit:Homodimer. Interacts with COPS5.|

The TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of TOP2A protein phosphorylated at Ser1213. This antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The TOP2A protein plays a crucial role in DNA replication and repair, making it an essential target for studying cellular processes and diseases such as cancer. The phosphorylation of TOP2A at Ser1213 has been implicated in regulating its enzymatic activity and DNA binding ability, further emphasizing the importance of this antibody in understanding the functional significance of TOP2A phosphorylation.

This rabbit polyclonal antibody has been meticulously developed using state-of-the-art techniques to ensure high specificity and sensitivity. It exhibits minimal cross-reactivity with other proteins, ensuring accurate and reliable results. The antibody has also been extensively validated using a variety of cell lines and tissues, guaranteeing its performance across different experimental conditions.

The TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and error-prone antibody dilutions. The antibody is also compatible with a wide range of secondary detection systems, enabling flexibility in experimental design.

In summary, the TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody is a highly reliable and versatile tool for the detection and quantification of phosphorylated TOP2A protein. Its exceptional specificity, sensitivity, and compatibility with various applications make it an invaluable asset for researchers studying DNA replication, repair, and related diseases.