TFR1 Rabbit Polyclonal Antibody

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand| the heditary hemochromatosis protein HFE| competes for binding with transferrin for an overlapping C-terminal binding site.|induction:Regulated by cellular iron levels through binding of the iron regulatory proteins| IRP1 and IRP2| to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.|miscellaneous:Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.|miscellaneous:Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis| pregnancy| irritable bowel syndrome and in HIV patients.|PTM:N- and O-glycosylated| phosphorylated and palmitoylated. The serum form is only glycosylated.|PTM:Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.|PTM:Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).|Belongs to the peptidase M28 family. M28B subfamily.|Contains 1 PA (protease associated) domain.|subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.|subunit:Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen| DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC.|

The TFR1 Rabbit Polyclonal Antibody is a highly specific and sensitive antibody designed for use in various research applications. This antibody is produced using high-quality rabbit polyclonal immunoglobulins, which have been purified and tested to ensure optimal performance. The TFR1 Rabbit Polyclonal Antibody is specifically designed to target the transferrin receptor 1 (TFR1) protein, which is a key component of the iron uptake pathway in cells. This antibody is ideal for use in a variety of applications, including western blotting, immunohistochemistry, and immunofluorescence. With its high specificity and sensitivity, the TFR1 Rabbit Polyclonal Antibody is an essential tool for researchers studying iron metabolism and related diseases.