Stat2 (Acetyl Lys384) Rabbit Polyclonal Antibody

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors| Jak kinases (TYK2 and JAK1) are activated| leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize| associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor| that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes| which drive the cell in an antiviral state.|PTM:Tyrosine phosphorylated in response to IFN-alpha.|Belongs to the transcription factor STAT family.|Contains 1 SH2 domain.|subcellular location:Translocated into the nucleus upon activation by IFN-alpha/beta.|subunit:Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein.|

The Stat2 (Acetyl Lys384) Rabbit Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Stat2 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the acetylated lysine 384 of human Stat2 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Stat2 (Acetyl Lys384) Rabbit Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. This antibody has been shown to specifically recognize the acetylated form of Stat2 protein and does not cross-react with other acetylated proteins or non-acetylated Stat2 protein.

This antibody is an essential tool for researchers studying the role of Stat2 protein in various cellular processes, including immune response, cell proliferation, and differentiation. The high specificity and sensitivity of this antibody make it an ideal choice for detecting and quantifying Stat2 protein in various biological samples, including cell lysates, tissue homogenates, and serum.

In summary, the Stat2 (Acetyl Lys384) Rabbit Polyclonal Antibody is a highly specific and sensitive antibody that is essential for researchers studying the role of Stat2 protein in various cellular processes. This antibody is supplied as a liquid formulation and has been extensively validated for its specificity and sensitivity in various applications.