Smad1(Phospho Ser214) Rabbit Polyclonal Antibody

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).|PTM:Phosphorylated on serine by BMP type 1 receptor kinase.|PTM:Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.|Belongs to the dwarfin/SMAD family.|Contains 1 MH1 (MAD homology 1) domain.|Contains 1 MH2 (MAD homology 2) domain.|subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.|subunit:Interacts with HGS| NANOG and ZCCHC12 (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit| CREB-binding protein (CBP)| p300| SMURF1| SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with LBXCOR1.|tissue specificity:Ubiquitous. Highest expression seen in the heart and skeletal muscle.|

The Smad1(Phospho Ser214) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Smad1 protein phosphorylated at Ser214. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring excellent performance and reliability in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Smad1 protein plays a crucial role in the transforming growth factor-beta (TGF-β) signaling pathway, which regulates various cellular processes such as cell proliferation, differentiation, and apoptosis. Phosphorylation of Smad1 at Ser214 is known to be a critical event in the activation of this pathway, making it an important target for research and diagnostic purposes.

With its exceptional specificity and sensitivity, the Smad1(Phospho Ser214) Rabbit Polyclonal Antibody enables accurate and reliable detection of phosphorylated Smad1 protein in various biological samples. Its high affinity for the target epitope ensures minimal cross-reactivity, resulting in precise and reproducible results.

This antibody has been extensively validated and optimized to provide consistent performance across different experimental conditions. Its robustness and reliability make it an ideal choice for researchers and scientists working in the fields of cell biology, molecular biology, and signal transduction.

The Smad1(Phospho Ser214) Rabbit Polyclonal Antibody is supplied in a convenient and ready-to-use format, allowing for easy integration into laboratory workflows. It is provided in a liquid form, ensuring ease of handling and minimizing the risk of sample contamination.

In summary, the Smad1(Phospho Ser214) Rabbit Polyclonal Antibody is a highly specific and sensitive tool that offers exceptional performance in the detection and analysis of phosphorylated Smad1 protein. Its reliability, robustness, and ease of use make it an invaluable asset for researchers and scientists in various fields of study.