RFX5 Rabbit Polyclonal Antibody

A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency| or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B| C| and D all lead to a deficiency in RFX| a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al.| 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.

The RFX5 Rabbit Polyclonal Antibody is a meticulously crafted immunological reagent, meticulously designed to detect and quantify the RFX5 protein in a wide range of biological samples. This antibody is meticulously produced by immunizing rabbits with a synthetic peptide that corresponds to the C-terminal region of the human RFX5 protein. As a result, the resulting polyclonal antibody demonstrates an exceptional level of affinity and specificity towards the RFX5 protein, rendering it an invaluable tool for a multitude of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The RFX5 Rabbit Polyclonal Antibody is conveniently supplied in a liquid form, ensuring ease of use and immediate availability for research purposes. Its reliability and cost-effectiveness make it an optimal solution for researchers who are dedicated to studying the intricate role of the RFX5 protein in various biological processes.

In summary, the RFX5 Rabbit Polyclonal Antibody is an exceptional immunological reagent that offers high specificity and sensitivity for the detection and quantification of the RFX5 protein. Its liquid form and ready-to-use nature make it an indispensable tool for researchers seeking to unravel the complexities of the RFX5 protein in diverse biological samples.