Skip to product information
1 of 1

BT Lab

SKU:BT-AP12244

RBL2(Phospho Ser952) Rabbit Polyclonal Antibody

RBL2(Phospho Ser952) Rabbit Polyclonal Antibody

Regular price $275.00 USD
Regular price Sale price $275.00 USD
Sale Sold out
Shipping calculated at checkout.
Size
Host
Ab type

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and| in particular| that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2| leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation| associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.|miscellaneous:G0-restricted expression.|PTM:During G0 and early G1 phase of the cell cycle| phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis.|Belongs to the retinoblastoma protein (RB) family.|subunit:Interacts with AATF. Interacts with SUV420H1 and SUV420H2 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4| E2F5| LIN9| LIN37| LIN52| LIN54| MYBL1| MYBL2| RBL1| RBL2| RBBP4| TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9| LIN37| LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RINT1.|

The RBL2(PHOSPHO SER952) Rabbit Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of RBL2 protein phosphorylated at serine 952. This antibody has been meticulously developed and validated to ensure exceptional performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

The RBL2(PHOSPHO SER952) Rabbit Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling accurate and precise quantification of RBL2 phosphorylation at serine 952. It has been rigorously tested to ensure minimal cross-reactivity with non-phosphorylated RBL2 or other proteins, ensuring reliable and reproducible results.

This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring batch-to-batch consistency and reliability. It has been extensively validated using a variety of experimental approaches, guaranteeing its suitability for a wide range of research applications.

The RBL2(PHOSPHO SER952) Rabbit Polyclonal Antibody is supplied in a convenient and user-friendly format, allowing for easy handling and storage. It is provided in a liquid form, ready for immediate use, eliminating the need for time-consuming reconstitution steps.

With its exceptional specificity, sensitivity, and reliability, the RBL2(PHOSPHO SER952) Rabbit Polyclonal Antibody is an indispensable tool for researchers studying RBL2 phosphorylation at serine 952. Its high performance and ease of use make it an ideal choice for a wide range of applications in molecular biology, cell biology, and cancer research.

View full details