PSME1 Rabbit Polyclonal Antibody

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes| a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base| which contains 6 ATPase subunits and 2 non-ATPase subunits| and a lid| which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome| the immunoproteasome| is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator| referred to as the 11S regulator or PA28| that replaces the 19S regulator. Three subunits (alpha| beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator| one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants.

The PSME1 Rabbit Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of PSME1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the N-terminal region of human PSME1 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards PSME1 protein, making it an ideal tool for various applications such as Western blotting, immunohistochemistry, and immunofluorescence. The PSME1 Rabbit Polyclonal Antibody is supplied as a purified IgG fraction, which has been affinity-purified using a PSME1 peptide column. This ensures that the antibody is free from non-specific binding and contaminants, thereby providing reliable and reproducible results. With its superior performance and quality, the PSME1 Rabbit Polyclonal Antibody is an essential tool for researchers studying the role of PSME1 protein in various biological processes.