PLOD1 Rabbit Polyclonal Antibody

Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene.

The PLOD1 Rabbit Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of PLOD1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human PLOD1 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards PLOD1 protein, making it an ideal tool for various applications such as Western blotting, immunohistochemistry, and ELISA.

The PLOD1 Rabbit Polyclonal Antibody is validated for use in human, mouse, and rat samples, and has been extensively tested for its specificity and sensitivity. It recognizes a single band of approximately 70 kDa in Western blot analysis of PLOD1 protein, and shows minimal cross-reactivity with other related proteins. This antibody is supplied as a purified IgG fraction, and is suitable for use in both research and diagnostic applications.

In summary, the PLOD1 Rabbit Polyclonal Antibody is a reliable and high-quality reagent that provides accurate and reproducible results in the detection and quantification of PLOD1 protein. Its high specificity and sensitivity make it an essential tool for researchers and clinicians working in the fields of cancer, fibrosis, and connective tissue disorders.