ODPX Rabbit Polyclonal Antibody

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits| E1| E2| and E3| two regulatory subunits| E1 kinase and E1 phosphatase| and a non-catalytic subunit| E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC| activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

The ODPX Rabbit Polyclonal Antibody is a highly specialized and meticulously crafted product designed to cater to the needs of researchers and scientists in the field of biotechnology. This antibody is derived from rabbits and exhibits exceptional specificity and sensitivity, making it an ideal tool for various applications such as immunohistochemistry, immunofluorescence, and Western blotting.

The ODPX Rabbit Polyclonal Antibody is meticulously produced using state-of-the-art techniques, ensuring the highest level of purity and quality. It has been extensively validated and optimized to provide reliable and reproducible results, enabling researchers to confidently pursue their scientific endeavors.

This antibody demonstrates a remarkable affinity towards its target antigen, allowing for precise and accurate detection. Its polyclonal nature further enhances its versatility, enabling it to recognize multiple epitopes on the target protein, thereby increasing the chances of successful detection.

The ODPX Rabbit Polyclonal Antibody is supplied in a convenient and user-friendly format, ensuring ease of use and storage. It is provided in a liquid form, eliminating the need for reconstitution, and is compatible with a wide range of experimental conditions and protocols.

With its exceptional performance and reliability, the ODPX Rabbit Polyclonal Antibody is an indispensable tool for researchers seeking to unravel the complexities of biological systems. Trust in its superior quality and unleash the full potential of your research with this remarkable antibody.