MMP8 (Cleaved-Leu101) Rabbit Polyclonal Antibody

Catalytic activity:Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7| this enzyme cleaves type III collagen more slowly than type I.|cofactor:Binds 2 zinc ions per subunit.|cofactor:Binds 3 calcium ions per subunit.|The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion| thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.|enzyme regulation:Cannot be activated without removal of the activation peptide.|Can degrade fibrillar type I| II| and III collagens.|Belongs to the peptidase M10A family.|Contains 4 hemopexin-like domains.|subcellular location:Stored in intracellular granules.|tissue specificity:Neutrophils.|

The MMP8 (Cleaved-Leu101) Rabbit Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of MMP8 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the cleaved Leu101 region of human MMP8 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the cleaved-Leu101 region of MMP8 protein, making it an ideal tool for studying the expression and function of this protein in various physiological and pathological processes.

The MMP8 (Cleaved-Leu101) Rabbit Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and ELISA. This antibody has been shown to detect MMP8 protein in a variety of human and animal tissues, including lung, liver, kidney, heart, and brain. Moreover, this antibody has been shown to detect MMP8 protein in various disease states, including cancer, inflammation, and cardiovascular disease.

The MMP8 (Cleaved-Leu101) Rabbit Polyclonal Antibody is supplied as a purified IgG fraction, which has been affinity-purified from rabbit serum using a column containing the synthetic peptide used for immunization. This antibody is provided in a liquid format, which is ready to use for various applications. The antibody is supplied in a buffer containing 0.02% sodium azide as a preservative.

In summary, the MMP8 (Cleaved-Leu101) Rabbit Polyclonal Antibody is a highly specific and sensitive immunological reagent that is ideal for studying the expression and function of MMP8 protein in various physiological and pathological processes. This antibody is extensively validated and supplied in a purified IgG fraction, making it an ideal tool for various applications, including Western blotting, immunohistochemistry, and ELISA.