MMP1 (Cleaved-Ile271) Rabbit Polyclonal Antibody

Catalytic activity:Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus| at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.|cofactor:Binds 2 zinc ions per subunit.|cofactor:Binds 4 calcium ions per subunit.|The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion| thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.|There are two distinct domains in this protein; the catalytic N-terminal| and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases).|enzyme regulation:Can be activated without removal of the activation peptide.|Cleaves collagens of types I| II| and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection| interacts and cleaves the secreted viral Tat protein| leading to a decrease in neuronal Tat's mediated neurotoxicity.|online information:Collagenase entry|PTM:Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.|Belongs to the peptidase M10A family.|Contains 4 hemopexin-like domains.|subunit:Interacts with HIV-1 Tat.|

Introducing the MMP1 (Cleaved-Ile271) Rabbit Polyclonal Antibody, a highly specific and reliable tool for the detection and analysis of cleaved MMP1 protein in various biological samples. This antibody has been meticulously developed using advanced immunization techniques, resulting in a high affinity and exceptional sensitivity towards the cleaved form of MMP1.

The MMP1 (Cleaved-Ile271) Rabbit Polyclonal Antibody exhibits outstanding performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its exceptional specificity ensures accurate and precise identification of the cleaved MMP1 protein, enabling researchers to gain valuable insights into its role in various physiological and pathological processes.

This antibody has been rigorously validated using a variety of experimental approaches, guaranteeing its reliability and reproducibility. Its robust performance is further enhanced by its compatibility with multiple species, including human, mouse, and rat, making it an ideal choice for researchers working with diverse model systems.

The MMP1 (Cleaved-Ile271) Rabbit Polyclonal Antibody is supplied in a convenient and user-friendly format, ensuring ease of use and storage. Each vial contains a sufficient quantity of antibody, allowing for multiple experiments and minimizing the need for frequent reordering.

In summary, the MMP1 (Cleaved-Ile271) Rabbit Polyclonal Antibody is a highly specific, sensitive, and reliable tool for the detection and analysis of cleaved MMP1 protein. Its exceptional performance, versatility, and ease of use make it an indispensable asset for researchers in the field of molecular biology, cancer research, and beyond.