Met(Phospho-Tyr1234/1235) Rabbit Polyclonal Antibody

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide| which has been shown to reduce lung fibrosis. Binding of its ligand| hepatocyte growth factor| induces dimerization and activation of the receptor| which plays a role in cellular survival| embryogenesis| and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma| hepatocellular carcinoma| and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.

The Met(Phospho-Tyr1234/1235) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Met protein phosphorylated at tyrosine residues 1234 and 1235. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring exceptional performance and reliability in various applications.

The Met protein, also known as hepatocyte growth factor receptor (HGFR), plays a crucial role in cell growth, survival, and migration. Phosphorylation of tyrosine residues 1234 and 1235 is a key event in the activation of Met signaling pathway, leading to downstream signaling cascades involved in cellular processes such as proliferation, differentiation, and angiogenesis.

The Met(Phospho-Tyr1234/1235) Rabbit Polyclonal Antibody exhibits outstanding specificity towards the phosphorylated form of Met, enabling precise detection and quantification of this critical post-translational modification. This antibody has been extensively validated in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence, ensuring its suitability for a wide range of research applications.

With its superior sensitivity and specificity, the Met(Phospho-Tyr1234/1235) Rabbit Polyclonal Antibody offers researchers a valuable tool to investigate the role of Met phosphorylation in cellular processes and disease pathogenesis. Its reliable performance and consistent results make it an indispensable asset for scientists working in the fields of cancer biology, signal transduction, and drug discovery.

Order the Met(Phospho-Tyr1234/1235) Rabbit Polyclonal Antibody today and unlock new insights into the intricate mechanisms of Met signaling pathway, advancing your research towards a deeper understanding of cellular biology and potential therapeutic targets.