LRP6(Phospho-Ser1490) Rabbit Polyclonal Antibody

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or| with Frizzled| a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation| proliferation| and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

The LRP6(Phospho-Ser1490) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of LRP6 protein phosphorylated at Ser1490. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring excellent performance and reproducibility.

LRP6, also known as low-density lipoprotein receptor-related protein 6, is a key component of the Wnt signaling pathway, which plays a crucial role in various cellular processes, including embryonic development, tissue homeostasis, and cell proliferation. Phosphorylation of LRP6 at Ser1490 has been shown to regulate its activity and downstream signaling events.

The LRP6(Phospho-Ser1490) Rabbit Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated LRP6 and other related proteins, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation, ready to use for immediate experimentation. It is provided in a convenient size of 100 µg, ensuring ample supply for multiple experiments. The LRP6(Phospho-Ser1490) Rabbit Polyclonal Antibody is suitable for use in both research and clinical settings, enabling scientists and clinicians to gain valuable insights into the role of LRP6 phosphorylation in various biological processes.

In summary, the LRP6(Phospho-Ser1490) Rabbit Polyclonal Antibody is a highly specific and sensitive tool that allows for the detection and analysis of LRP6 protein phosphorylated at Ser1490. With its excellent performance and reproducibility, this antibody is an essential asset for researchers and clinicians studying the Wnt signaling pathway and its implications in various cellular processes.