LRP6(Phospho Thr1479) Rabbit Polyclonal Antibody

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or| with Frizzled| a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation| proliferation| and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

The LRP6(Phospho Thr1479) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of LRP6 protein phosphorylated at threonine 1479. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring reliable and reproducible results.

LRP6, also known as low-density lipoprotein receptor-related protein 6, plays a crucial role in the Wnt signaling pathway, which is involved in various cellular processes such as embryonic development, tissue homeostasis, and cell proliferation. Phosphorylation of LRP6 at threonine 1479 has been shown to regulate its activity and downstream signaling events.

The LRP6(Phospho Thr1479) Rabbit Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated LRP6 and other related proteins, ensuring accurate and reliable detection of phosphorylated LRP6.

This antibody is supplied as a liquid formulation, ready to use for immediate application. It is provided in a convenient size, allowing for multiple experiments and minimizing wastage. The LRP6(Phospho Thr1479) Rabbit Polyclonal Antibody is manufactured under strict quality control standards, ensuring consistent performance and batch-to-batch reproducibility.

In summary, the LRP6(Phospho Thr1479) Rabbit Polyclonal Antibody is a valuable tool for researchers studying the Wnt signaling pathway and its involvement in various cellular processes. Its high specificity, sensitivity, and reliability make it an essential component of any study aiming to elucidate the role of phosphorylated LRP6 in cellular signaling.