LAT(Phospho Tyr255) Rabbit Polyclonal Antibody

Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling| both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores| PKC activation| MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1| GRB2| GRAP2| and other signaling molecules.|miscellaneous:Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell-induced activation of PLC| maybe by inducing

the dephosphorylation of LAT.|PTM:Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.|PTM:Phosphorylated on tyrosines by ZAP-70 upon TCR activation| or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement.|subcellular location:Present in lipid rafts.|subunit:When phosphorylated| interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2| GRAP| GRAP2| PLCG1 and PLCG2. Interacts indirectly with CBL| SOS| VAV| and LCP2. Interacts with SHB| SKAP2 and CLNK (By similarity). Interacts with FCGR1A.|tissue specificity:Expressed in thymus| T-cells| NK cells| mast cells and| at lower levels| in spleen. Present in T-cells but not B-cells (at protein level).|

vThe LAT(Phospho Tyr255) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of LAT protein phosphorylated at tyrosine 255. This antibody is produced using advanced rabbit polyclonal technology, ensuring high affinity and specificity towards the target protein.

LAT, also known as Linker for Activation of T cells, plays a crucial role in T cell receptor signaling and activation. Phosphorylation of tyrosine 255 on LAT is a key event in the initiation of downstream signaling cascades, leading to T cell activation and immune response.

The LAT(Phospho Tyr255) Rabbit Polyclonal Antibody has been rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate detection and quantification of phosphorylated LAT protein in complex biological samples.

This antibody is supplied as a liquid formulation, ready for immediate use. It has been optimized for compatibility with a wide range of experimental conditions, ensuring reliable and reproducible results. The antibody is provided in a convenient size, allowing for multiple experiments without compromising its quality.

Researchers and scientists in the fields of immunology, cell biology, and signal transduction will greatly benefit from the LAT(Phospho Tyr255) Rabbit Polyclonal Antibody. Its exceptional performance and reliability make it an indispensable tool for studying T cell activation, immune response, and related signaling pathways.

Order your LAT(Phospho Tyr255) Rabbit Polyclonal Antibody today and unlock new insights into the intricate mechanisms of T cell signaling and immune regulation.