KCNK2 Rabbit Polyclonal Antibody

This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened| however| by certain anesthetics| membrane stretching| intracellular acidosis| and heat. Three transcript variants encoding different isoforms have been found for this gene.

The KCNK2 Rabbit Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of KCNK2 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human KCNK2 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The KCNK2 Rabbit Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes a single band of approximately 50 kDa in Western blot analysis of human, mouse, and rat brain tissue lysates. In addition, it shows strong staining of KCNK2 protein in human and mouse brain tissue sections in immunohistochemistry and immunofluorescence assays.

This antibody is an essential tool for researchers studying the function and regulation of KCNK2 protein in various physiological and pathological processes, including neuronal excitability, pain perception, and epilepsy. It is also useful for the development of diagnostic and therapeutic strategies targeting KCNK2-related disorders.

In summary, the KCNK2 Rabbit Polyclonal Antibody is a reliable and high-quality reagent that provides accurate and reproducible results in various applications. Its specificity, sensitivity, and versatility make it an ideal choice for researchers working in the field of neuroscience and related disciplines.