Huntingtin (Acetyl Lys442) Rabbit Polyclonal Antibody

Huntingtin is a disease gene linked to Huntington's disease| a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded| unstable trinucleotide repeat in the huntingtin gene| which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls| and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large| spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widel

Introducing the Huntingtin (Acetyl Lys442) Rabbit Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of neurodegenerative disorders. This high-quality antibody is specifically tailored to target the acetylated form of Lysine 442 on the Huntingtin protein, enabling precise detection and analysis of this crucial modification.

Crafted with utmost precision and expertise, this rabbit polyclonal antibody exhibits exceptional specificity and sensitivity, ensuring accurate and reliable results. Its unique design allows for efficient recognition and binding to the acetylated Lysine 442 site on the Huntingtin protein, enabling researchers to delve deeper into the intricate mechanisms underlying neurodegenerative diseases.

The Huntingtin (Acetyl Lys442) Rabbit Polyclonal Antibody is meticulously validated through rigorous quality control measures, guaranteeing optimal performance and reproducibility. Its exceptional affinity for the acetylated Lysine 442 epitope ensures minimal cross-reactivity, thereby minimizing any potential interference from non-specific binding events.

This antibody is an invaluable tool for a wide range of applications, including immunohistochemistry, immunofluorescence, and Western blotting. Its versatility allows for seamless integration into various experimental protocols, empowering researchers to explore the role of acetylation at Lysine 442 in the context of Huntington's disease and related disorders.

With its superior performance and reliability, the Huntingtin (Acetyl Lys442) Rabbit Polyclonal Antibody is an indispensable asset for scientists and researchers striving to unravel the intricate molecular mechanisms underlying neurodegenerative disorders. Invest in this exceptional antibody today and unlock new insights into the pathogenesis and potential therapeutic interventions for these debilitating conditions.