Histone H4 (Tri Methyl Lys21) Rabbit Polyclonal Antibody

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin| limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation| DNA repair| DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones| also called histone code| and nucleosome remodeling.

|PTM:Acetylation at Lys-6| Lys-9| Lys-13 and Lys-17 occurs in coding regions of the genome but not in heterochromatin.|PTM:Citrullination at Arg-4 by PADI4 impairs methylation.|PTM:Monomethylated| dimethylated or trimethylated at Lys-21. Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing.|PTM:Monomethylation at Arg-4 by PRMT1 favors acetylation at Lys-9 and Lys-13. Demethylation is performed by JMJD6.|PTM:Sumoylated| which is associated with transcriptional repression.|PTM:Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation.

This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.|Belongs to the histone H4 family.|subunit:The nucleosome is a histone octamer containing two molecules each of H2A| H2B| H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|