Histone H4 (Di Methyl Lys21) Rabbit Polyclonal Antibody

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin| limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation| DNA repair| DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones| also called histone code| and nucleosome remodeling.|PTM:Acetylation at Lys-6| Lys-9| Lys-13 and Lys-17 occurs in coding regions of the genome but not in heterochromatin.|PTM:Citrullination at Arg-4 by PADI4 impairs methylation.|PTM:Monomethylated| dimethylated or trimethylated at Lys-21. Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing.|PTM:Monomethylation at Arg-4 by PRMT1 favors acetylation at Lys-9 and Lys-13.

Demethylation is performed by JMJD6.|PTM:Sumoylated| which is associated with transcriptional repression.|PTM:Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.|Belongs to the histone H4 family.|subunit:The nucleosome is a histone octamer containing two molecules each of H2A| H2B| H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|

The Histone H4 (Di Methyl Lys21) Rabbit Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Histone H4 protein that has undergone di-methylation at lysine 21 residue. This antibody is produced using high-quality rabbit polyclonal antibodies that have been extensively validated for their specificity and sensitivity. The antibody is ideal for use in various applications, including Western blotting, immunoprecipitation, and immunohistochemistry.

The Histone H4 (Di Methyl Lys21) Rabbit Polyclonal Antibody is a reliable tool for researchers studying epigenetic modifications and chromatin remodeling. It is supplied in a convenient format and is ready to use for research purposes. The antibody is manufactured to the highest standards of quality and purity, ensuring consistent and reproducible results. With its exceptional performance and reliability, the Histone H4 (Di Methyl Lys21) Rabbit Polyclonal Antibody is an essential tool for any researcher studying epigenetic modifications and chromatin remodeling.