Histone H2B (Acetyl Lys35) Rabbit Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A| H2B| H3| and H4).

The chromatin fiber is further compacted through the interaction of a linker histone| H1| with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene| which is found in the large histone gene cluster on chromosome 6p22-p21.3.

The Histone H2B (Acetyl Lys35) Rabbit Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Histone H2B protein acetylated at Lysine 35. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring exceptional sensitivity and specificity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

Histone H2B is a crucial component of nucleosomes, playing a vital role in chromatin structure and gene regulation. Acetylation of Lysine 35 on Histone H2B has been implicated in various biological processes, including transcriptional activation and DNA repair. Therefore, the ability to accurately detect and quantify Histone H2B acetylated at Lysine 35 is of utmost importance in understanding the intricate mechanisms underlying these processes.

This antibody exhibits excellent performance in a wide range of sample types, including cell lysates, tissue extracts, and purified proteins. It has been rigorously validated to ensure minimal cross-reactivity with non-acetylated forms of Histone H2B and other histone proteins. Additionally, it demonstrates high sensitivity, enabling the detection of low-abundance acetylated Histone H2B species.

The Histone H2B (Acetyl Lys35) Rabbit Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is provided in a convenient size, ensuring cost-effectiveness and minimizing wastage.

With its exceptional specificity, sensitivity, and ease of use, the Histone H2B (Acetyl Lys35) Rabbit Polyclonal Antibody is an indispensable tool for researchers studying epigenetics, chromatin biology, and gene regulation. Trust in its performance to advance your understanding of the intricate mechanisms governing cellular processes.