Histone H2B (Acetyl Lys117) Rabbit Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A| H2B| H3| and H4).

The chromatin fiber is further compacted through the interaction of a linker histone| H1| with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.

The Histone H2B (Acetyl Lys117) Rabbit Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Histone H2B protein acetylated at Lysine 117. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring exceptional sensitivity and specificity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

Histone H2B is a crucial component of nucleosomes, playing a vital role in chromatin structure and gene regulation. Acetylation of Lysine 117 on Histone H2B has been implicated in various biological processes, including transcriptional activation and DNA repair. Therefore, the ability to accurately detect and quantify Histone H2B acetylated at Lysine 117 is of utmost importance in understanding the intricate mechanisms underlying these processes.

This antibody has been extensively validated for its performance and specificity. It exhibits minimal cross-reactivity with non-acetylated Histone H2B and other acetylated lysine residues, ensuring reliable and accurate results. Additionally, it demonstrates excellent sensitivity, allowing for the detection of low-abundance acetylated Histone H2B in complex biological samples.

The Histone H2B (Acetyl Lys117) Rabbit Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is provided in a convenient size, ensuring cost-effectiveness and minimizing wastage.

In summary, the Histone H2B (Acetyl Lys117) Rabbit Polyclonal Antibody is a highly specific, sensitive, and reliable tool for the detection and analysis of Histone H2B protein acetylated at Lysine 117. Its exceptional performance and versatility make it an invaluable asset for researchers studying chromatin structure, gene regulation, and various biological processes.