Histone H2B (Acetyl Lys109) Rabbit Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A| H2B| H3| and H4).

The chromatin fiber is further compacted through the interaction of a linker histone| H1| with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.

The Histone H2B (Acetyl Lys109) Rabbit Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of acetylated Histone H2B at Lysine 109. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring exceptional sensitivity and specificity in various applications, including Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP).

Histone H2B is a crucial component of nucleosomes, playing a vital role in chromatin structure and gene regulation. Acetylation of Histone H2B at Lysine 109 has been implicated in various biological processes, including transcriptional activation and DNA repair. Therefore, the ability to accurately detect and quantify acetylated Histone H2B is essential for understanding the intricate mechanisms underlying these processes.

The Histone H2B (Acetyl Lys109) Rabbit Polyclonal Antibody exhibits exceptional specificity towards acetylated Histone H2B at Lysine 109, ensuring minimal cross-reactivity with other histone modifications or non-acetylated forms of Histone H2B. This specificity guarantees reliable and accurate results, enabling researchers to confidently investigate the role of acetylated Histone H2B in their experimental systems.

Furthermore, this antibody has been extensively validated in various experimental conditions, ensuring consistent and reproducible results. Its high sensitivity allows for the detection of low abundance acetylated Histone H2B, even in limited sample quantities. The antibody's robust performance across multiple applications, including Western blotting, immunohistochemistry, and ChIP, provides researchers with flexibility and versatility in their experimental design.

In summary, the Histone H2B (Acetyl Lys109) Rabbit Polyclonal Antibody is a valuable tool for researchers studying the role of acetylated Histone H2B in chromatin structure and gene regulation. Its exceptional specificity, sensitivity, and versatility make it an ideal choice for various applications, enabling accurate and reliable detection and analysis of acetylated Histone H2B at Lysine 109.