Histone H2A.Z (Acetyl Lys12) Rabbit Polyclonal Antibody

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin| limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation| DNA repair| DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones| also called histone code| and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.|mass spectrometry:

Monoisotopic| not modified PubMed:16457589|PTM:Acetylated on Lys-5| Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.|PTM:Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.|PTM:Not phosphorylated.|Belongs to the histone H2A family.|subunit:The nucleosome is a histone octamer containing two molecules each of H2A| H2B| H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP.|

The Histone H2A.Z (Acetyl Lys12) Rabbit Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Histone H2A.Z (Acetyl Lys12) in various biological samples. This antibody is produced using high-quality rabbit polyclonal antibodies that have been extensively validated for their specificity and sensitivity. The antibody is designed to recognize Histone H2A.Z (Acetyl Lys12) with high affinity and specificity, making it an ideal tool for researchers studying epigenetic modifications and chromatin remodeling.

The antibody is suitable for use in a variety of applications, including Western blotting, immunoprecipitation, and immunofluorescence. With its high specificity and sensitivity, the Histone H2A.Z (Acetyl Lys12) Rabbit Polyclonal Antibody is an essential tool for researchers studying the role of histone modifications in gene expression and chromatin structure.