Histone H2A (Acetyl Lys6) Rabbit Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A| H2B| H3| and H4) form an octamer| around which approximately 146 bp of DNA is wrapped in repeating units| called nucleosomes.

The linker histone| H1| interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.

The Histone H2A (Acetyl Lys6) Rabbit Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of Histone H2A protein that has been acetylated at lysine 6 residue. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the acetylated lysine 6 region of Histone H2A protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the acetylated Histone H2A protein, making it an ideal tool for various applications in research and diagnostics.

The Histone H2A (Acetyl Lys6) Rabbit Polyclonal Antibody is suitable for use in various immunoassays, including Western blotting, immunohistochemistry, and immunofluorescence. It has been validated for use in a wide range of species, including human, mouse, rat, and other mammalian species. This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

In summary, the Histone H2A (Acetyl Lys6) Rabbit Polyclonal Antibody is a reliable and high-quality reagent that can be used for the detection and quantification of acetylated Histone H2A protein in various biological samples. Its high specificity and sensitivity make it an essential tool for researchers and clinicians working in the fields of epigenetics, chromatin biology, and cancer research.