Histone H1 (Acetyl Lys66/63/64) Rabbit Polyclonal Antibody

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A| H2B| H3| and H4) form an octamer| around which approximately 146 bp of DNA is wrapped in repeating units| called nucleosomes.

The linker histone| H1| interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

The Histone H1 (Acetyl Lys66/63/64) Rabbit Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Histone H1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the acetylated Lys66/63/64 region of Histone H1. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Histone H1 (Acetyl Lys66/63/64) Rabbit Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. This antibody has been shown to specifically recognize the acetylated Lys66/63/64 region of Histone H1 and does not cross-react with other histone proteins or non-histone proteins.

This antibody is an essential tool for researchers studying epigenetic modifications and chromatin structure. It can be used to investigate the role of Histone H1 acetylation in gene expression, DNA replication, and DNA repair. The Histone H1 (Acetyl Lys66/63/64) Rabbit Polyclonal Antibody is available in various sizes to meet the needs of different research projects. It is a reliable and high-quality antibody that can provide accurate and reproducible results.