HDAC1 (Acetyl Lys432) Rabbit Polyclonal Antibody

Catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.|Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A| H2B| H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation| cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|PTM:Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.

|PTM:Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.|Belongs to the histone deacetylase family. Type 1 subfamily.|subunit:Part of the core histone deacetylase (HDAC) complex composed of HDAC1| HDAC2| RBBP4 and RBBP7. The core complex associates with MTA2| MBD2| MBD3| MTA1L1| CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex| or with SIN3| SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1| HDAC2| HMG20B/BRAF35| AOF2/LSD1| RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2| ZNF217| ZMYM3| GSE1 and GTF2I. Associates with the 9-1-1 complex; interacts with HUS1.

Found in a complex with DNMT3A and HDAC7. Interacts with BCOR| BRMS1L| DAXX| DNMT1| EP300| HCFC1| NFE4| PCAF| PHB2| MIER1| KDM4A| MINT| NRIP1| PRDM6| RERE| SETDB1| SUV39H1| TGIF| TGIF2| UHRF1| UHRF2 and ZNF541. Interacts with the non-histone region of H2AFY. Interacts with HDAC9. Component of a mSin3A corepressor complex that contains SIN3A| SAP130| SUDS3/SAP45| ARID4B/SAP180| HDAC1 and HDAC2. Interacts with BANP| CBFA2T3 and KDM5B. Interacts with SAP30L. Interacts with E4F1. Interacts with KFL1 (By similarity). Interacts with SV40 large T antigen.|tissue specificity:Ubiquitous| with higher levels in heart| pancreas and testis| and lower levels in kidney and brain.|

The HDAC1 (Acetyl Lys432) Rabbit Polyclonal Antibody is a highly specific and reliable tool for the detection and quantification of HDAC1 protein in various biological samples. This antibody has been developed using a rabbit host and exhibits exceptional affinity towards the acetylated Lys432 residue of the HDAC1 protein.

With its superior sensitivity and specificity, this antibody enables accurate and precise analysis of HDAC1 protein levels in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It is particularly suitable for studying the acetylation status of HDAC1 and its role in epigenetic regulation.

The HDAC1 (Acetyl Lys432) Rabbit Polyclonal Antibody has been rigorously validated to ensure consistent and reproducible results. It exhibits minimal cross-reactivity with other HDAC isoforms, ensuring reliable and specific detection of HDAC1. Furthermore, it has been extensively tested in various cell lines and tissues, demonstrating its robust performance across different experimental conditions.

This antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex preparation steps. The antibody is also available in different sizes to accommodate various experimental requirements.

In summary, the HDAC1 (Acetyl Lys432) Rabbit Polyclonal Antibody is a highly reliable and specific tool for the detection and quantification of HDAC1 protein. Its exceptional sensitivity, specificity, and ease of use make it an ideal choice for researchers studying HDAC1 and its involvement in epigenetic regulation.