GPX4 Rabbit Polyclonal Antibody

The protein encoded by this gene belongs to the glutathione peroxidase family| members of which catalyze the reduction of hydrogen peroxide| organic hydroperoxides and lipid hydroperoxides| and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates| which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus| it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase| as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein| containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon| which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure| designated the Sec insertion sequence (SECIS) element| that is necessary for the recognition of UGA as a Sec codon| rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

The GPN2 Rabbit Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of GPN2 protein expression in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a specific region of the GPN2 protein. It has been extensively validated for its specificity and sensitivity, ensuring accurate and reproducible results.

The GPN2 Rabbit Polyclonal Antibody exhibits exceptional affinity towards the GPN2 protein, making it an ideal choice for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes endogenous levels of GPN2 protein in various species, including human, mouse, and rat.

With its superior performance, this antibody enables researchers to investigate the role of GPN2 in cellular processes and disease mechanisms. It provides a valuable tool for studying protein-protein interactions, protein localization, and protein expression patterns in different tissues and cell types.

The GPN2 Rabbit Polyclonal Antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex antibody preparation procedures. The antibody is also available in different sizes to accommodate various experimental needs.

In summary, the GPN2 Rabbit Polyclonal Antibody is a highly specific and reliable tool that enables accurate detection and analysis of GPN2 protein expression. Its exceptional affinity, versatility, and ease of use make it an essential component for researchers studying GPN2-related processes and diseases.