FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody

disease:A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with MLL/HRX. The result is a rogue activator protein.|Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.|pharmaceutical:A constitutively active FOXO4 mutant where phosphorylation sites Thr-32| Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival| transformation and tumorigenicity.|PTM:Acetylation by CBP| which is induced by peroxidase stress| inhibits transcriptional activity. Deacetylation by SIRT1 is NAD-dependent and stimulates transcriptional activity.|PTM:Phosphorylation by PKB/AKT1 inhibits transcriptional activity and is responsible for cytoplasmic localization.|Contains 1 fork-head DNA-binding domain.|subcellular location:When phosphorylated| translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation.|subunit:Interacts with CBP| MYOCD| SIRT1| SRF and YWHAZ. Acetylated by CBP and deacetylated by SIRT1. Binding of YWHAZ inhibits DNA-binding.|tissue specificity:Heart| brain| placenta| lung| liver| skeletal muscle| kidney and pancreas. Isoform zeta is most abundant in the liver| kidney| and pancreas.|

The FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of FoxO4 protein in various biological samples. This antibody has been developed using advanced immunization techniques and exhibits exceptional affinity and selectivity towards the acetylated form of FoxO4 at Lys407 residue.

The FoxO4 protein is a member of the Forkhead box O (FoxO) transcription factor family, which plays a crucial role in regulating various cellular processes, including cell cycle arrest, apoptosis, and oxidative stress response. The acetylation of FoxO4 at Lys407 has been shown to modulate its transcriptional activity and subcellular localization, thereby influencing its biological functions.

This polyclonal antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with other FoxO family members and non-specific proteins, ensuring reliable and accurate results.

The FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage. It is suitable for use in a wide range of applications, including basic research, drug discovery, and clinical diagnostics.

In summary, the FoxO4 (Acetyl Lys407) Rabbit Polyclonal Antibody is a valuable tool for researchers and scientists studying the intricate mechanisms of FoxO4 protein regulation. Its high specificity, sensitivity, and reliability make it an indispensable asset in elucidating the role of FoxO4 in various physiological and pathological processes.