FOS Rabbit Polyclonal Antibody

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer| c-fos and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction| cell proliferation and differentiation.|PTM:Constitutively sumoylated by SUMO1| SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is| itself| inhibited by Ras-activated phosphorylation on Thr-232.|PTM:Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated| in vitro| by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232| induced by HA-RAS| activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation.|Belongs to the bZIP family.|Belongs to the bZIP family. Fos subfamily.|Contains 1 bZIP domain.|subunit:Heterodimer with JUN. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB.|

The FOS Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of FOS protein expression. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring reliable and reproducible results.

The FOS Rabbit Polyclonal Antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional specificity, binding only to the FOS protein and not cross-reacting with other proteins.

With its high sensitivity, this antibody allows for the detection of even low levels of FOS protein expression, making it an ideal choice for researchers studying FOS-related pathways and processes. Its robust performance ensures accurate and reliable results, enabling precise analysis and interpretation of experimental data.

The FOS Rabbit Polyclonal Antibody is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming and complex antibody preparation. It is available in various sizes to suit different experimental requirements.

In summary, the FOS Rabbit Polyclonal Antibody is a valuable tool for researchers in the field of molecular biology and biochemistry. Its high specificity, sensitivity, and reliability make it an essential component for the study of FOS protein expression and its associated biological processes.