FLT3(Phospho-Tyr589/591) Rabbit Polyclonal Antibody

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain| which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis| proliferation| and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

The FLT3(Phospho-Tyr589/591) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of FLT3 protein phosphorylated at tyrosine residues 589 and 591. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring excellent performance and reproducibility.

The FLT3 protein plays a crucial role in the regulation of cell growth and differentiation, particularly in hematopoietic stem cells. Phosphorylation of FLT3 at tyrosine residues 589 and 591 is known to be associated with the activation of downstream signaling pathways, leading to cell proliferation and survival.

This antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

The FLT3(Phospho-Tyr589/591) Rabbit Polyclonal Antibody is supplied as a liquid formulation, ready to use for immediate experimentation. It is provided in a convenient size of 100 µg, ensuring ample supply for multiple experiments.

With its exceptional specificity, sensitivity, and reliability, the FLT3(Phospho-Tyr589/591) Rabbit Polyclonal Antibody is an indispensable tool for researchers studying FLT3 signaling pathways and its role in various physiological and pathological processes.