ER alpha (Acetyl Lys303) Rabbit Polyclonal Antibody

Composed of three domains: a modulating N-terminal domain| a DNA-binding domain and a C-terminal steroid-binding domain.|Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.|online information:Estrogen receptor entry|polymorphism:Genetic variations in ESR1 are correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density| disrutption of bone microarchitecture| and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.|PTM:Glycosylated; contains N-acetylglucosamine| probably O-linked.|PTM:Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.|Belongs to the nuclear hormone receptor family.|Belongs to the nuclear hormone receptor family. NR3 subfamily.|Contains 1 nuclear receptor DNA-binding domain.|subunit:Interacts with SLC30A9 (By similarity). Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3| NCOA5 and NCOA6 coactivators| leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2| PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2| FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol.|

The ER alpha (Acetyl Lys303) Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of estrogen receptor alpha (ER alpha) protein in various biological samples. This antibody has been developed using a rabbit polyclonal approach, ensuring high affinity and specificity towards the acetylated lysine residue at position 303 of the ER alpha protein.

The ER alpha protein plays a crucial role in mediating the effects of estrogen hormones in various physiological processes, including cell growth, differentiation, and development. The acetylation of lysine residue 303 has been shown to modulate the activity and function of ER alpha, making it an important target for research and therapeutic interventions.

This antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of ER alpha protein in complex biological samples.

The ER alpha (Acetyl Lys303) Rabbit Polyclonal Antibody is supplied as a purified and concentrated solution, ensuring optimal performance and ease of use. It is provided in a convenient size and format, allowing for multiple experiments and applications.

In summary, the ER alpha (Acetyl Lys303) Rabbit Polyclonal Antibody is a valuable tool for researchers and scientists studying the role and function of ER alpha protein in various biological processes. Its high specificity, sensitivity, and reliability make it an essential component of any research project involving ER alpha protein analysis.