EphA4 Rabbit Polyclonal Antibody

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events| particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene.

The EphA4 Rabbit Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of EphA4 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human EphA4 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The EphA4 Rabbit Polyclonal Antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to specifically recognize EphA4 protein in human, mouse, and rat tissues, with minimal cross-reactivity to other Eph receptor family members. The antibody has also been shown to be highly sensitive, with a detection limit of 0.1 ng of EphA4 protein.

This antibody is an essential tool for researchers studying the role of EphA4 in various biological processes, including neuronal development, synaptic plasticity, and cancer progression. Its high specificity and sensitivity make it an ideal choice for detecting EphA4 protein in complex biological samples, such as tissue lysates and cell extracts.

In summary, the EphA4 Rabbit Polyclonal Antibody is a reliable and effective tool for the detection of EphA4 protein in various biological samples. Its high specificity, sensitivity, and versatility make it an essential reagent for researchers studying the function and regulation of EphA4 in health and disease.