DNA-PK(Phospho Thr2609) Rabbit Polyclonal Antibody

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.|enzyme regulation:Inhibited by wortmannin. Activity of the enzyme seems to be attenuated by autophosphorylation.|Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes| suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence

The DNA-PK(Phospho Thr2609) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of DNA-dependent protein kinase (DNA-PK) phosphorylated at threonine 2609. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring reliable and reproducible results.

DNA-PK is a crucial enzyme involved in the repair of DNA double-strand breaks and plays a vital role in maintaining genomic stability. Phosphorylation of DNA-PK at threonine 2609 is known to regulate its activity and function. Therefore, the DNA-PK(Phospho Thr2609) Rabbit Polyclonal Antibody serves as an invaluable tool for researchers studying DNA repair mechanisms and investigating the role of DNA-PK in various cellular processes.

This antibody has been extensively validated for its specificity and sensitivity through various experimental techniques, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated DNA-PK and other related proteins, ensuring accurate and reliable results.

The DNA-PK(Phospho Thr2609) Rabbit Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The antibody is stored at -20°C, ensuring long-term stability and preserving its activity.

In summary, the DNA-PK(Phospho Thr2609) Rabbit Polyclonal Antibody is a highly specific and sensitive tool that enables researchers to investigate the phosphorylation status of DNA-PK at threonine 2609. Its reliable performance and extensive validation make it an ideal choice for studying DNA repair mechanisms and exploring the role of DNA-PK in various cellular processes.