DFF45(Cleaved-Thr225) Rabbit Polyclonal Antibody

Inhibitor of the caspase-activated DNase (DFF40).|PTM:Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.|PTM:Phosphorylated upon DNA damage| probably by ATM or ATR.|Contains 1 CIDE-N domain.|subunit:Heterodimer of DFFA and DFFB.|

The DFF45 (Cleaved-Thr225) Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of DFF45 protein in various biological samples. This antibody has been developed using advanced immunization techniques and exhibits exceptional affinity and selectivity towards the cleaved form of DFF45 at Thr225 residue.

The DFF45 protein, also known as DNA fragmentation factor subunit alpha, plays a crucial role in the process of DNA fragmentation during apoptosis. Cleavage of DFF45 at Thr225 is a key event in the activation of this protein and subsequent DNA fragmentation. Therefore, the detection and analysis of cleaved DFF45 at Thr225 is of great importance in understanding the mechanisms underlying apoptosis.

This rabbit polyclonal antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other proteins, ensuring accurate and reliable results.

The DFF45 (Cleaved-Thr225) Rabbit Polyclonal Antibody is supplied as a liquid formulation, ready to use for various applications. It is provided in a convenient size and concentration, allowing for easy handling and storage. The antibody is produced in compliance with strict quality control standards, ensuring consistent performance and reproducibility.

In summary, the DFF45 (Cleaved-Thr225) Rabbit Polyclonal Antibody is a valuable tool for researchers studying apoptosis and DNA fragmentation. Its high specificity, sensitivity, and reliability make it an essential component in the investigation of DFF45 protein dynamics and its role in cellular processes.