Desmoplakin(Phospho-Ser165/166) Rabbit Polyclonal Antibody

This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas| including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants.

The Desmoplakin(Phospho-Ser165/166) Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of Desmoplakin protein phosphorylated at Ser165/166. This antibody has been rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

Desmoplakin is a critical component of desmosomes, which are intercellular junctions that provide mechanical strength to tissues. Phosphorylation of Desmoplakin at Ser165/166 has been implicated in the regulation of desmosome assembly and stability. Therefore, the ability to accurately detect and quantify phosphorylated Desmoplakin is essential for understanding the molecular mechanisms underlying desmosome function.

The Desmoplakin(Phospho-Ser165/166) Rabbit Polyclonal Antibody exhibits exceptional specificity and sensitivity, ensuring reliable and reproducible results. It has been extensively characterized using various cell lines and tissues, demonstrating its robust performance across different experimental conditions.

This antibody is supplied as a purified and lyophilized format, ensuring long-term stability and ease of use. It can be reconstituted in a suitable buffer for immediate application or aliquoted for future use. The recommended working dilution range has been optimized to provide optimal signal-to-noise ratio while minimizing background noise.

In summary, the Desmoplakin(Phospho-Ser165/166) Rabbit Polyclonal Antibody is a valuable tool for researchers studying desmosome biology and its role in tissue integrity. Its high specificity, sensitivity, and versatility make it an indispensable reagent for a wide range of applications, enabling precise and accurate analysis of phosphorylated Desmoplakin.