NF2(Phospho Ser518) Polyclonal Antibody

This gene encodes a protein that is similar to some members of the ERM (ezrin| radixin| moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins| proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults| significant expression is found in Schwann cells| meningeal cells| lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.

The NF2(Phospho Ser518) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of NF2 protein phosphorylated at Serine 518. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

The NF2 protein, also known as Merlin, plays a crucial role in cell growth regulation and tumor suppression. Phosphorylation of NF2 at Serine 518 has been implicated in various cellular processes, including cell adhesion, cytoskeletal organization, and cell signaling pathways.

This polyclonal antibody is raised in rabbits using a synthetic phospho-peptide corresponding to the phosphorylated Serine 518 region of the NF2 protein. It has been extensively validated for specificity and sensitivity through various experimental approaches, including Western blotting, immunohistochemistry, and immunofluorescence.

The NF2(Phospho Ser518) Polyclonal Antibody exhibits excellent performance in detecting phosphorylated NF2 protein in a wide range of sample types, including cell lysates, tissue extracts, and cultured cells. It provides a reliable and accurate measurement of NF2 phosphorylation levels, enabling researchers to investigate the role of NF2 in various biological processes and disease states.

With its high specificity and sensitivity, this antibody is an invaluable tool for researchers studying NF2 signaling pathways, tumor biology, and potential therapeutic targets. It is supplied in a convenient format, allowing for easy handling and storage.

In summary, the NF2(Phospho Ser518) Polyclonal Antibody is a reliable and high-quality reagent that enables precise detection and quantification of phosphorylated NF2 protein. Its exceptional performance and versatility make it an essential tool for researchers in the field of cell biology, cancer research, and molecular medicine.