Dab1(Phospho Tyr220) Rabbit Polyclonal Antibody

The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.|Adapter molecule functioning in neural development. May regulate SIAH1 activity.|PTM:Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (By similarity). Also phosphorylated on Ser-524 independently of reelin signaling.|Contains 1 PID domain.|subunit:Associates with the SH2 domains of SRC| FYN and ABL. Interacts with DAB2IP and SIAH1 (By similarity). Interacts with LRP1.|

The Dab1(Phospho-Tyr220) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Dab1 protein phosphorylated at tyrosine 220. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring reliable and reproducible results.

The Dab1 protein plays a crucial role in neuronal development and migration, as well as in the regulation of synaptic plasticity. Phosphorylation of Dab1 at tyrosine 220 is known to be involved in various signaling pathways, including the Reelin signaling pathway, which is essential for proper brain development.

This antibody has been extensively validated for its specificity and sensitivity in various experimental conditions, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated Dab1 protein, ensuring accurate and reliable detection of the phosphorylated form.

The Dab1(Phospho-Tyr220) Rabbit Polyclonal Antibody is supplied as a liquid formulation, ready to use for various applications. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering.

In summary, the Dab1(Phospho-Tyr220) Rabbit Polyclonal Antibody is a valuable tool for researchers studying neuronal development, migration, and synaptic plasticity. Its high specificity, sensitivity, and reliability make it an essential component of any laboratory working in the field of neuroscience.